Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection
نویسندگان
چکیده
منابع مشابه
Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection
Retinol plays a vital role in the immune response to infection, yet proteins that mediate retinol transport during infection have not been identified. Serum amyloid A (SAA) proteins are strongly induced in the liver by systemic infection and in the intestine by bacterial colonization, but their exact functions remain unclear. Here we show that mouse and human SAAs are retinol binding proteins. ...
متن کاملBiochemical indicators of vitamin A deficiency: serum retinol and serum retinol binding protein.
Two biochemical indicators are currently recommended for determining whether vitamin A deficiency (VAD) is a public health problem: serum retinol and serum retinol-binding protein (RBP). After consideration of 40 data sets and the original rationale for previously proposed cut-offs, a cut-off for serum retinol concentration was proposed at <0.70 micro mol/L (20 micro g/dL) in > or =15% of the s...
متن کاملA radioimmunoassay for retinol-binding protein in serum and urine.
In this radioimmunoassay for human retinol-binding protein (RBP), sample (serum, diluted as much as 3600-fold; or urine, diluted or undiluted) or calibrant (purified RBP in phosphate buffer containing bovine serum albumin) is incubated with 125I-labeled RBP and rabbit anti-human RBP antiserum for 24 h before separation with second antibody/polyethylene glycol. The assay's sensitivity is 5 micro...
متن کاملEffect of alcohol consumption on serum concentration of 25-hydroxyvitamin D3, retinol, and retinol-binding protein.
The effect of chronic alcohol consumption on the concentration of 25-hydroxyvitamin D3, total retinol, and retinol-binding protein in serum was studied in chronic alcoholics (n = 12) and controls (n = 19). Ethanol intake during the last year was 178 +/- 116 and 3.7 +/- 4.5 g/day, respectively (p less than 0.002). Of the alcoholics, 58% had a concentration of 25-hydroxyvitamin D3 below lower lim...
متن کاملRetinol and retinol-binding protein: gut integrity and circulating immunoglobulins.
Vitamin A (retinol) is required to maintain immunity and epithelial turnover and is a key micronutrient needed for combating infection. Vitamin A actions on the immune system are diverse and cannot be accounted for by a single effect or mechanism. The actions of retinol in maintaining gut integrity in humans and immunoglobulin levels in mice was investigated. For 30 children, performance on the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: eLife
سال: 2014
ISSN: 2050-084X
DOI: 10.7554/elife.03206